Microbiology
Attenuated vaccines are chemically fixed and incapable of entering host cells; inactivated vaccines always contain whole live organisms that replicate slowly
Attenuated vaccines are equivalent to variolation and are always safer than modern inactivated vaccines because they were used historically without adverse events
Attenuated vaccines only induce passive immunity by supplying ready-made antibodies, while inactivated vaccines stimulate active memory formation through persistent replication
Attenuated vaccines contain organisms that can replicate in the host but have reduced virulence; inactivated vaccines contain organisms or components that cannot replicate