on-of-visible-antigenantibody-lattices-in-agglutination-and-precipitation-assays

Question

At the molecular level, which property of antibodies most directly enables the formation of visible antigen–antibody lattices in agglutination and precipitation assays?

Accepted Answer

Multivalency (multiple antigen-binding sites) that allows antibodies to bind two or more antigen epitopes simultaneously, forming cross-links between antigens.

Answer

The glycosylation pattern on the Fc region which directly causes antigens to aggregate through carbohydrate bridging.

Answer

Antibody-mediated complement fixation which is required to clump antigens together into visible aggregates in both precipitation and agglutination assays.

Answer

The enzymatic activity of antibodies that polymerizes antigen molecules into large insoluble complexes independent of binding valency.