ian-effective-dose-ed50-is-10-mg-based-on-ti-assess-the-drugs-selective-toxicity

Question

Calculate the therapeutic index (TI) of a hypothetical antimicrobial when the median toxic dose in humans (TD50) is 200 mg and the median effective dose (ED50) is 10 mg. Based on TI, assess the drug's selective toxicity.

Accepted Answer

Therapeutic index = 20; indicates a reasonable margin of safety and selective toxicity in typical clinical contexts

Answer

Therapeutic index = 190 indicating extremely high safety and no need for monitoring

Answer

Therapeutic index = 0.05; indicates the drug is highly toxic to humans and unsafe for use

Answer

Therapeutic index cannot be calculated from TD50 and ED50 values