Which clinical scenario would most directly impair the delivery of absorbed monosaccharides from the intestine to the liver?

Severe atrophy of the gastric mucosa, which would directly block monosaccharide transport across enterocytes in the jejunum, an anatomically mismatched impact because gastric mucosa does not perform small intestinal absorption.

Obstruction of the thoracic duct, which would prevent monosaccharide transport to the liver by blocking lymph flow carrying sugar-loaded chylomicrons, a misunderstanding since monosaccharides are transported in blood not lymph.

A defect in pancreatic lipase secretion, leading to immediate failure of monosaccharide absorption, which confuses lipid digestion enzymes with carbohydrate absorption processes.

Thrombosis of the hepatic portal vein, because it would obstruct direct venous flow from the intestines to the liver and disrupt first-pass hepatic metabolism of absorbed monosaccharides.