Which clinical sign is most specifically associated with severe vitamin A deficiency affecting vision?

Uncontrolled hypercalcemia and nephrocalcinosis from overactive bone resorption and abnormal vitamin D signaling.

Night blindness (difficulty seeing in low light) progressing to xerophthalmia and corneal ulceration.

Spontaneous bruising and mucosal bleeding due to impaired prothrombin activation.

Peripheral neuropathy and paresthesia of the lower limbs due to demyelination of sensory neurons.