Which of these statements correctly indicates a metabolic limitation humans have regarding double-bond configurations?

Human enzymes convert cis double bonds into saturated bonds preferentially, making cis fats equivalent to saturated fats metabolically.

Humans lack efficient enzymatic systems to convert trans double bonds into cis configurations, so trans fats tend to accumulate and disrupt metabolism.

Humans can freely interconvert cis and trans double bonds using desaturases in the gut microbiome during digestion.

Humans produce high levels of isomerases that convert all dietary trans fats into beneficial omega‑3 cis fatty acids.