Create a short intervention plan that leverages dietary sources (not high-dose supplements) to support antioxidant defenses in older adults. Which combination best synthesizes biochemical principles and practical dietary guidance?

Advise routine megadoses of isolated vitamin E and C for all older adults because dietary patterns are irrelevant and supplements are always more effective than whole foods at delivering antioxidants uniformly to every tissue.

Promote a varied diet rich in fruits and vegetables (vitamin C and phytochemicals), nuts and seeds (vitamin E), adequate protein to maintain glutathione synthesis, and inclusion of healthy fats (to aid absorption of fat-soluble antioxidants), combined with reducing pro-oxidant exposures like smoking—this leverages complementary antioxidant systems rather than single high-dose supplements.

Recommend exclusive reliance on a single antioxidant-rich food like blueberries and avoid all fats to ensure antioxidants remain water-soluble, because simplicity and single-food strategies are proven superior to diverse dietary patterns for antioxidant protection.

Suggest complete avoidance of fruits and vegetables because their phytochemicals interfere with pharmacologic antioxidants and therefore make pharmaceutical interventions less effective; instead prioritize processed fortification products for predictable dosing.