a-laboratory-study-in-rats-shows-that-compound-y-improves-insulin-sensitivity-by

Question

A laboratory study in rats shows that compound Y improves insulin sensitivity by affecting liver enzyme Z. Which human measurements would best translate this mechanistic evidence into a feasible human follow-up study?

Accepted Answer

Measure fasting glucose, fasting insulin, HOMA-IR, and perform an oral glucose tolerance test in humans randomized to compound Y or placebo to check whether the mechanism translates to improved insulin sensitivity

Answer

Rely solely on animal organ histology endpoints and assume the same histological changes occur identically in humans without measuring metabolic markers

Answer

Measure only body weight as the primary outcome because insulin sensitivity changes are irrelevant for translation from animals

Answer

Only collect self-reported food frequency questionnaires because mechanistic enzyme changes cannot be captured in humans