Create a short, evidence-based dietary plan aimed at lowering expression of pro-inflammatory cytokines in an at-risk adult. Which combination most plausibly applies nutrigenomics principles to achieve the goal?

Suggest removing all dietary fats and proteins completely for two weeks as the only method to reduce cytokine gene transcription, without attention to vitamins or fiber.

Advise exclusive consumption of synthetic amino acid supplements that directly insert anti-inflammatory sequences into DNA, thereby permanently turning off cytokine genes.

Increase omega-3 fatty acid intake (e.g., fatty fish, flaxseed), increase fiber and phytochemical-rich fruits and vegetables, reduce saturated and trans fats and refined carbohydrates, and ensure adequate vitamin D and polyphenol intake to modulate epigenetic and signaling pathways that lower pro-inflammatory gene expression.

Recommend a diet high in processed red meats, refined sugars, and trans fats because these components are known to increase DNA methylation of anti-inflammatory genes and thereby lower inflammatory cytokine expression.