How would a protein found in the nonpolar interior of a membrane fold?

The proteins would fold so that the nonpolar residues are on the outside and the polar residues are on the inside.

The proteins would fold so that the polar residues are on the outside and the nonpolar residues are on the inside.

The proteins would fold so that the polar and nonpolar residues are on the outside.

The proteins would fold so that the polar and nonpolar residues are on the inside.