give-the-estimated-pka-value-of-the-indicated-proton-in-the-structure-of-3-methy

Question

Using your knowledge of important pK_{a} values, estimate the pK_{a} value of the indicated proton and explain your choice.

Accepted Answer

pK_{a} = 5; The indicated proton belongs to the carboxylic acid functional group.

Answer

pK_{a} = 16; The indicated proton is part of a hydroxyl group, so its pK_{a} is that of an alcohol.

Answer

pK_{a} = −2; The emphasized proton is part of $$O^{+}$$—H.

Answer

pK_{a} = 20; The hydrogen emphasized is attached to an α-carbon.

Using your knowledge of important pKa values, estimate the pKa value of the indicated proton and explain your choice.