in-the-fischer-esterification-mechanism-what-is-the-first-step-when-reacting-an-

Question

In the Fischer esterification mechanism, what is the first step when reacting an amino acid carboxylic acid group with an alcohol?

Accepted Answer

Protonation of the carbonyl oxygen to increase electrophilicity.

Answer

Formation of a tetrahedral intermediate.

Answer

Deprotonation of the alcohol.

Answer

Nucleophilic attack by the alcohol on the carbonyl carbon.