34. Nucleic Acids

Which of the following statements is false?

Clinical trials include the use of DNA-binding drugs that facilitate the breaking of double-stranded DNA in their function. A hypothetical drug used in the treatment of leukemia requires interaction with the grooves of DNA. If the minor groove is A–T rich and the major groove is G–C rich, which of the following statements can be true?

One turn of a DNA sequence is comprised of 30% guanine (G). Calculate the approximate number of hydrogens bonds likely to be found within this DNA sequence.  

One turn of a DNA sequence is comprised of 15% adenine (A). If the bonding energies of A–T and G–C are 24 kJ/mol and 18 kJ/mol respectively, calculate the approximate total bonding energy in this one turn.