Question 1

Which of the following is the main psychoactive compound found in marijuana?

Accepted Answer

Delta-9-tetrahydrocannabinol ($$ \Delta^9-$$THC)

Question 2

Which metabolic pathway is primarily responsible for the inactivation of THC in the human body?

Accepted Answer

Conversion to 11-hydroxy-$$ \Delta^9 -$$THC and then to 11-nor-9-carboxy-$$ \Delta^9 -$$THC (THC-COOH)

Question 3

Which of the following statements about the absorption and distribution of THC is CORRECT?

Accepted Answer

THC is highly lipophilic and accumulates in adipose tissue, leading to a long detection window in the body.

Question 4

Which receptor is primarily responsible for the psychoactive effects of THC in the central nervous system?

Accepted Answer

CB1 receptor

Question 5

Which of the following best describes the mechanism by which CB1 receptor activation inhibits neurotransmitter release?

Accepted Answer

Inhibition of presynaptic calcium entry and opening of potassium channels

Question 6

Which of the following is a TRUE statement regarding the difference between CB1 and CB2 receptors?

Accepted Answer

CB1 receptors are primarily found in the CNS, while CB2 receptors are mainly in the immune system and peripheral tissues.

Question 7

Which of the following drugs can completely block the adverse cognitive effects of THC, and by what mechanism?

Accepted Answer

Rimonabant, by antagonizing CB1 receptors

Question 8

Which of the following statements about endocannabinoids is CORRECT?

Accepted Answer

Anandamide and 2-AG are retrograde messengers that modulate neurotransmitter release.

Question 9

Which of the following is a clinical use of THC or its derivatives?

Accepted Answer

Treatment of nausea and vomiting in chemotherapy patients

Question 10

Which of the following statements about cannabidiol (CBD) is TRUE?

Accepted Answer

CBD has low affinity for CB1 and CB2 receptors and does not produce psychoactive effects.

Question 11

Which of the following best explains why THC can be detected in urine for weeks after last use?

Accepted Answer

THC is stored in adipose tissue and released slowly over time.

Question 12

Which of the following is a common symptom associated with cannabis withdrawal?

Accepted Answer

Irritability

Question 13

Which of the following statements about cocaine is CORRECT?

Accepted Answer

Cocaine is a non-selective monoamine reuptake inhibitor, blocking DAT, NET, and SERT.

Question 14

Which of the following is a physiological effect of cocaine use?

Accepted Answer

Increased heart rate and blood pressure

Question 15

Which of the following best describes the relationship between synaptic dopamine levels and mood in cocaine users?

Accepted Answer

High synaptic dopamine levels are associated with euphoria.

Question 16

Which of the following is a potential treatment option for cocaine withdrawal symptoms?

Accepted Answer

Dopamine D2 receptor antagonist

Question 17

Which of the following statements about amphetamines is TRUE?

Accepted Answer

Amphetamines increase synaptic monoamine levels by promoting release and blocking reuptake.

Question 18

Which of the following is a medical use for amphetamines?

Accepted Answer

Treatment of attention deficit hyperactivity disorder (ADHD)

Question 19

Which of the following statements about MDMA (ecstasy) is CORRECT?

Accepted Answer

MDMA increases serotonin release at the synaptic level.

Question 20

Which of the following is a long-term neurotoxic effect observed after MDMA abuse?

Accepted Answer

Decreased serotonergic fiber density in the brain

Study Notes: Marijuana, Psychostimulants, and Hallucinogens – Chemical and Pharmacological Aspects

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