Question 1

Which of the following best describes the mechanism of action of nonsteroidal anti-inflammatory drugs (NSAIDs)?

Accepted Answer

They inhibit COX-1 and COX-2 enzymes, which are required for prostaglandin production.

Question 2

A patient presents with a history of peptic ulcer disease and is seeking pain relief. Which medication should be avoided due to increased risk of gastrointestinal adverse events?

Accepted Answer

Ibuprofen

Question 3

Which of the following statements about acetaminophen is CORRECT?

Accepted Answer

It is metabolized in the liver and can cause hepatotoxicity in overdose.

Question 4

A 7-year-old child with a viral infection is prescribed medication for fever. Which drug should be avoided and why?

Accepted Answer

Aspirin, due to the risk of Reye syndrome

Question 5

Which of the following is a unique property of selective COX-2 inhibitors like celecoxib compared to nonselective NSAIDs?

Accepted Answer

They selectively block prostaglandins associated with pain and inflammation, sparing those with protective effects.

Question 6

A patient is admitted with jaundice, vomiting, and CNS excitement 36 hours after ingesting a large quantity of acetaminophen. Which treatment is most beneficial if administered within 8 hours of ingestion?

Accepted Answer

Acetylcysteine

Question 7

Which of the following is NOT an indication for regular low-dose aspirin therapy?

Accepted Answer

Treatment of gout

Question 8

A patient with chronic alcohol abuse is at increased risk for which adverse effect when taking acetaminophen?

Accepted Answer

Hepatotoxicity

Question 9

Which of the following best explains why NSAIDs are not recommended for visceral pain?

Accepted Answer

They are ineffective for pain originating from internal organs.

Question 10

A patient with gout is prescribed allopurinol. What is the primary mechanism of action of this medication?

Accepted Answer

It reduces serum uric acid levels.

Question 11

Which of the following is a contraindication for NSAID use during pregnancy?

Accepted Answer

All of the above

Question 12

A patient presents with acute gout and is prescribed colchicine. What is the primary therapeutic effect of colchicine?

Accepted Answer

It inhibits the migration of white blood cells into tissues containing urate crystals.

Question 13

Which of the following statements about prostaglandins is TRUE?

Accepted Answer

They are chemical mediators found in most body tissues.

Question 14

A patient is brought to the emergency department 2 hours after ingesting a potentially toxic dose of acetaminophen. Which initial intervention is most appropriate?

Accepted Answer

Perform gastric lavage and administer activated charcoal

Question 15

Which of the following is a distinguishing feature of acetaminophen compared to aspirin?

Accepted Answer

Acetaminophen lacks anti-inflammatory activity.

Question 16

A patient with a history of GI bleeding is prescribed pain medication. Which of the following is the safest option?

Accepted Answer

Acetaminophen

Question 17

Which of the following is a sign of acetaminophen toxicity that may appear 24 to 48 hours after overdose?

Accepted Answer

Increased liver function test levels

Question 18

Which of the following is NOT a contraindication for NSAID use?

Accepted Answer

Migraine headache

Question 19

A patient with rheumatoid arthritis is prescribed meloxicam. To which class of NSAIDs does this drug belong?

Accepted Answer

Oxicam derivatives

Question 20

Which of the following best explains why acetylcysteine is most beneficial when given within 8 hours after acetaminophen overdose?

Accepted Answer

It prevents further formation of toxic metabolites.

Drug Therapy to Decrease Pain, Fever, and Inflammation: Medical Terminology Study Notes

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