Chronic pancreatitis contributes to the development of pancreatic cancer by:

• A. Promoting chronic inflammation with repeated acinar cell injury and regeneration.
• B. Increasing lipase secretion that mutates ductal cells.
• C. Causing persistent hyperinsulinemia that transforms pancreatic tissue.
• D. Blocking all pancreatic enzyme production leading to necrosis and malignancy.

Answer: (A)