Sara is HIV-negative and wants to become pregnant with her partner Mateo, who is HIV-positive. Which of the following strategies gives Sara the lowest practical risk of acquiring HIV while still allowing conception?

• A. Mateo should stop antiretroviral therapy (ART) and the couple should have unprotected sex only during Sara's fertile days.
• B. Sara should take daily oral PrEP and Mateo should use condoms at all times, including during fertile days.
• C. Sara should take daily oral PrEP and Mateo should use condoms except during Sara's fertile days so they can try to conceive.
• D. Sara should take PrEP only on the days she and Mateo have sex and Mateo should not use condoms on any day.

Answer: (C)