Comprehensive Study Notes: Cardiovascular, Immune, Respiratory, and Digestive Systems

{"type":"doc","content":[{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Cardiovascular System"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Pericardium & Heart Anatomy"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"The heart is protected and supported by several specialized structures that ensure its function and integrity."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Pericardium:"},{"type":"text","text":" A serous membrane that surrounds the heart, preventing overfilling and reducing friction."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Endocardium:"},{"type":"text","text":" The inner lining of the heart chambers, distinct from the endothelium of blood vessels."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Endothelium:"},{"type":"text","text":" Simple squamous epithelium lining all blood vessels, providing a smooth surface for blood flow."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Chordae tendineae:"},{"type":"text","text":" Tendinous cords anchoring the atrioventricular (AV) valves, preventing prolapse during ventricular contraction."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Papillary muscles:"},{"type":"text","text":" Muscles that contract to keep the chordae tendineae taut during ventricular systole."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Interventricular septum:"},{"type":"text","text":" The wall separating the right and left ventricles."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Heart Valves"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Heart valves ensure unidirectional blood flow through the heart by opening and closing in response to pressure changes."}]},{"type":"table","content":[{"type":"tableRow","content":[{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Valve"}]}]},{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Location / Function"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Tricuspid (right AV)"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Between right atrium and right ventricle; has chordae tendineae"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Bicuspid / Mitral (left AV)"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Between left atrium and left ventricle; has chordae tendineae; prevents backflow from LV to LA"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Pulmonary semilunar"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Right ventricle → pulmonary trunk; NO chordae tendineae"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Aortic semilunar"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Left ventricle → aorta; NO chordae tendineae"}]}]}]}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Valves open and close due to pressure changes, not nerve signals."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"1st heart sound (lub):"},{"type":"text","text":" AV valves close at the start of ventricular systole."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"2nd heart sound (dub):"},{"type":"text","text":" Semilunar valves close at the end of ventricular systole."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Path of Blood Through the Heart"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Blood flows through the heart in a specific sequence, ensuring oxygenation and systemic distribution."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Systemic return:"},{"type":"text","text":" Body tissues → Superior/Inferior Vena Cava → Right Atrium → Tricuspid valve → Right Ventricle → Pulmonary semilunar valve → Pulmonary trunk → Pulmonary arteries → Lungs"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Pulmonary return:"},{"type":"text","text":" Lungs → Pulmonary veins (oxygenated) → Left Atrium → Bicuspid/Mitral valve → Left Ventricle → Aortic semilunar valve → Aorta → Body"}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/anp/sub_images/1317d588_image_1.png","alt":"Diagram of blood flow through the heart","title":null,"width":null,"height":null}},{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/anp/sub_images/1317d588_image_2.png","alt":"Pulmonary veins and arteries oxygenation","title":null,"width":null,"height":null}}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Key Concept:"},{"type":"text","text":" Pulmonary veins carry oxygenated blood to the heart; pulmonary arteries carry deoxygenated blood away from the heart to the lungs."}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Cardiac Cycle"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"The cardiac cycle describes the sequence of events in one heartbeat, including contraction and relaxation phases."}]},{"type":"table","content":[{"type":"tableRow","content":[{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Phase"}]}]},{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"What Happens"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Atrial systole"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"SA node initiates; atria contract, AV valves open, semilunar valves closed"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Ventricular systole"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Ventricles contract, blood ejected through semilunar valves, AV valves closed"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Diastole"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"All chambers relax, passive ventricular filling, AV valves open, semilunar valves closed"}]}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/anp/sub_images/1317d588_image_3.png","alt":"Phases of the cardiac cycle","title":null,"width":null,"height":null}}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Cardiac Conduction System"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"The heart's electrical system coordinates contraction, ensuring efficient pumping."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"SA node:"},{"type":"text","text":" Pacemaker in right atrium; initiates heartbeat."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"AV node:"},{"type":"text","text":" Delays impulse before passing to ventricles."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"AV Bundle (Bundle of His) → Bundle Branches → Purkinje fibers:"},{"type":"text","text":" Conduct impulses through ventricles."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Conduction order:"},{"type":"text","text":" SA node → AV node → AV Bundle → Bundle branches → Purkinje fibers."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Ventricles contract apex-to-base (upward) to push blood toward semilunar valves."}]}]}]},{"type":"table","content":[{"type":"tableRow","content":[{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"ECG Wave"}]}]},{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Event"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"P wave"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Atrial depolarization → atrial systole follows"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"QRS complex"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Ventricular depolarization → ventricular systole"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"T wave"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Ventricular repolarization (relaxation)"}]}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Cardiac Arrhythmias"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Arrhythmias are abnormal heart rhythms that can affect cardiac output and health."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Bradycardia:"},{"type":"text","text":" Persistent resting HR < 60 bpm"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Tachycardia:"},{"type":"text","text":" Persistent resting HR > 100 bpm; can be caused by SA node hyperactivity"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Asystole:"},{"type":"text","text":" Complete absence of electrical and mechanical activity (flatline)"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Ventricular fibrillation:"},{"type":"text","text":" Chaotic, uncoordinated ventricular contractions"}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Cardiac Output & Blood Pressure"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Cardiac output and blood pressure are critical for tissue perfusion and homeostasis."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Cardiac Output (CO):"},{"type":"text","text":" "},{"type":"inlineMath","attrs":{"latex":"CO = HR \\times SV"}}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Stroke volume (SV):"},{"type":"text","text":" Volume of blood ejected per ventricular beat"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"If SV decreases → CO decreases → BP decreases → HR increases to compensate (homeostasis)"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Sympathetic NS activation increases HR, SV, and vasoconstriction (increases BP)"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Parasympathetic NS (acetylcholine at pacemaker) decreases HR"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Norepinephrine/adrenal medulla activation increases HR"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Blood pressure is highest in arteries, lowest in veins"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Response to high BP: vessels vasodilate; to low BP: increased HR, vasoconstriction, increased force of contraction"}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/anp/sub_images/1317d588_image_4.png","alt":"Cardiac output equation and blood pressure","title":null,"width":null,"height":null}},{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/anp/sub_images/1317d588_image_5.png","alt":"Anaphylactic shock and vasodilation","title":null,"width":null,"height":null}}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Key Concept:"},{"type":"text","text":" Anaphylactic shock causes massive vasodilation and dangerous BP drop due to histamine release."}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Blood Vessels"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Blood vessels transport blood throughout the body and are specialized for their functions."}]},{"type":"table","content":[{"type":"tableRow","content":[{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Vessel Type"}]}]},{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Key Features"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Arteries"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Carry blood away from heart; highest pressure; thickest wall is tunica media"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Capillaries"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Exchange vessels; one cell thick; filtration at arterial end, reabsorption at venous end"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Veins"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Return blood to heart; low pressure; contain one-way valves; aided by skeletal muscle contraction and respiratory pump"}]}]}]}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Fluid moves out of capillaries on arterial end via filtration (hydrostatic pressure)"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Excess fluid enters lymphatics at venous end; becomes lymph"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Peristalsis moves food in digestive tract, not blood in veins"}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Immune & Lymphatic System"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Lymphatic Vessels"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"The lymphatic system returns excess tissue fluid to the bloodstream and provides immune surveillance."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"One-way system; moves fluid toward the heart"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Lymphatic capillaries are more permeable than blood capillaries (minivalves in walls)"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Flow: Lymphatic capillaries → Collecting vessels → Lymph nodes → Lymphatic trunks → Subclavian veins"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Thoracic duct collects lymph from both legs and empties into left subclavian vein"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Right lymphatic duct drains upper right body only"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Movement aided by skeletal muscle contraction and breathing"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Lymph is filtered by lymph nodes before returning to the cardiovascular system"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Edema: Excess fluid in tissues causing swelling"}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Lymph Nodes"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Lymph nodes filter lymph, removing pathogens and debris."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Large clusters in cervical (neck) and axillary (armpit) regions"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Do not filter blood or deliver O2 to tissues"}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Lymphoid Organs"}]},{"type":"table","content":[{"type":"tableRow","content":[{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Organ"}]}]},{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Key Facts"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Thymus"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Active during youth; shrinks with age; site of T cell development/maturation"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Spleen"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Filters blood; removes old RBCs; stores platelets; clears bacteria/viruses"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Tonsils"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Surround pharynx; protect against inhaled/ingested pathogens"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Appendix"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Attached to cecum of large intestine"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Peyer's Patches"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Lymphoid tissue in wall of small intestine (ileum)"}]}]}]}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"MALT: Mucosa-Associated Lymphoid Tissue in respiratory and digestive systems"}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/anp/sub_images/1317d588_image_6.png","alt":"Spleen filters blood, lymph nodes filter lymph","title":null,"width":null,"height":null}}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Key Concept:"},{"type":"text","text":" Spleen filters blood; lymph nodes filter lymph. Thymus is the site of T cell maturation."}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Innate (Non-Specific) Defenses"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Innate defenses provide immediate, non-specific protection against pathogens."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"First line:"},{"type":"text","text":" Physical/chemical barriers (skin, mucous membranes, lysozymes)"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Second line:"},{"type":"text","text":" Internal responses (phagocytosis, natural killer cells, inflammation, fever)"}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/anp/sub_images/1317d588_image_7.png","alt":"Innate defenses overview","title":null,"width":null,"height":null}}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Key Concept:"},{"type":"text","text":" Innate defenses are not antigen-specific, do not generate memory cells, and include both first and second lines of defense."}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"The Inflammatory Response"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Inflammation is a protective response to tissue injury or 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