Which sequence correctly describes the JAK-STAT signaling pathway?

• A. Cytokine binds to receptor, JAK is recruited, STAT is phosphorylated, gene expression is altered
• B. Cytokine binds to receptor, adenylate cyclase is activated, cAMP is produced, gene expression is altered
• C. Cytokine binds to receptor, calcium is released, calmodulin is activated, gene expression is altered
• D. Cytokine binds to receptor, DAG is produced, PKC is activated, gene expression is altered

Answer: (A)