Which statement correctly differentiates endocrine hormones from paracrine hormones?

• A. Endocrine hormones affect only nearby cells, while paracrine hormones travel through the bloodstream.
• B. Both endocrine and paracrine hormones travel long distances to affect target cells.
• C. Paracrine hormones are always lipid-based, while endocrine hormones are not.
• D. Endocrine hormones travel long distances through the bloodstream, while paracrine hormones affect nearby cells.

Answer: (D)