A student claims that in both size exclusion chromatography and gel electrophoresis, smaller molecules elute first. How would you correct this misconception?

• A. Agree with the student, as both techniques work the same way.
• B. Explain that in size exclusion chromatography, larger molecules elute first due to their inability to enter the pores.
• C. Explain that in both techniques, smaller molecules elute first due to their size.
• D. Explain that in size exclusion chromatography, smaller molecules elute first due to their ability to enter the pores.

Answer: (B)