What is the relationship between substrate concentration, allosteric constant, and initial reaction velocity in the concerted model?

• A. Increasing substrate concentration increases the allosteric constant and initial reaction velocity.
• B. Increasing substrate concentration has no effect on the allosteric constant or initial reaction velocity.
• C. Increasing substrate concentration decreases the allosteric constant and increases initial reaction velocity.
• D. Increasing substrate concentration increases the allosteric constant and decreases initial reaction velocity.

Answer: (C)