A protein sequence contains several consecutive tryptophan residues. How might this affect the alpha helix structure?

• A. It will cause the helix to form more tightly.
• B. It will stabilize the helix due to increased hydrophobic interactions.
• C. It will have no effect on the helix structure.
• D. It will destabilize the helix due to steric hindrance from bulky side chains.

Answer: (D)