In designing a drug that targets an alpha helix in a protein, which factor should be considered to ensure the drug does not disrupt the helix?

• A. Ensure the drug increases the pH of the environment.
• B. Ensure the drug does not introduce charged groups near the helix.
• C. Ensure the drug contains proline residues.
• D. Ensure the drug forms covalent bonds with the helix.

Answer: (B)