How does Le Chatelier's principle explain the equilibrium shift in hemoglobin's oxygen release upon BPG binding?

• A. BPG binding has no effect on the equilibrium of oxygen release.
• B. BPG binding shifts the equilibrium to the left, decreasing oxygen release.
• C. BPG binding stabilizes the equilibrium, maintaining constant oxygen release.
• D. BPG binding shifts the equilibrium to the right, increasing oxygen release.

Answer: (D)