Why is BPG binding to the t state of hemoglobin significant for oxygen release in tissues?

• A. BPG binding destabilizes the t state, reducing oxygen release in tissues.
• B. BPG binding has no effect on oxygen release in tissues.
• C. BPG binding stabilizes the t state, promoting oxygen release in tissues.
• D. BPG binding stabilizes the r state, promoting oxygen release in tissues.

Answer: (C)