How does a decrease in blood pH in the tissues affect hemoglobin's oxygen binding affinity?

• A. Decreased blood pH in the tissues increases hemoglobin's oxygen binding affinity.
• B. Decreased blood pH in the tissues decreases hemoglobin's carbon dioxide binding affinity.
• C. Decreased blood pH in the tissues decreases hemoglobin's oxygen binding affinity.
• D. Decreased blood pH in the tissues has no effect on hemoglobin's oxygen binding affinity.

Answer: (C)