In a scenario where a person is exercising vigorously, how does hemoglobin transition between the R state and T state to facilitate oxygen delivery?

• A. Hemoglobin transitions from the T state to the R state in the tissues, binding more oxygen due to decreased CO2 and H+ concentrations.
• B. Hemoglobin transitions from the T state to the R state in the lungs, releasing CO2 and H+ and binding oxygen.
• C. Hemoglobin transitions from the R state to the T state in the tissues, releasing oxygen due to increased CO2 and H+ concentrations.
• D. Hemoglobin remains in the R state in both the lungs and tissues, maintaining high oxygen affinity.

Answer: (C)