In a high-altitude environment, how do hemoglobin carbonation and protonation affect oxygen transport and release in muscle tissues?

• A. Low CO2 and H+ concentrations at high altitude prevent hemoglobin carbonation and protonation, inhibiting oxygen release in muscle tissues.
• B. Low CO2 and H+ concentrations at high altitude enhance hemoglobin carbonation and protonation, promoting oxygen release in muscle tissues.
• C. High CO2 and H+ concentrations at high altitude prevent hemoglobin carbonation and protonation, inhibiting oxygen release in muscle tissues.
• D. High CO2 and H+ concentrations at high altitude enhance hemoglobin carbonation and protonation, promoting oxygen release in muscle tissues.

Answer: (D)