Why are new enzymes required in gluconeogenesis to reverse the irreversible reactions of glycolysis?

• A. The irreversible reactions are not involved in gluconeogenesis.
• B. The irreversible reactions have very negative delta G values, requiring different enzymes to proceed in the reverse direction.
• C. The irreversible reactions produce toxic intermediates that need to be bypassed.
• D. The irreversible reactions are too slow, necessitating faster enzymes for gluconeogenesis.

Answer: (B)