Evaluate the impact of PrPSC aggregation in the brain tissue.

• A. PrPSC aggregation increases synaptic plasticity, aiding memory formation.
• B. PrPSC aggregation enhances neural connectivity, improving brain function.
• C. PrPSC aggregation reduces inflammation, protecting brain tissue.
• D. PrPSC aggregation leads to spongiform lesions, causing neurodegenerative diseases.

Answer: (D)