How does prion-induced protein misfolding contribute to the progression of scrapie in animals?

• A. Misfolded prions cause the breakdown of synaptic connections, leading to paralysis.
• B. Misfolded prions increase the production of myelin, enhancing nerve conduction.
• C. Misfolded prions stimulate the growth of new neurons, improving brain function.
• D. Misfolded prions accumulate and aggregate, leading to spongiform lesions in the brain.

Answer: (D)