Given a protein with a mix of hydrophobic and hydrophilic amino acids, predict the likely distribution of these amino acids in the folded protein structure.

Which type of amino acid is most likely to be found on the exterior of a protein?

What does Leventhal's paradox suggest about the protein folding process?

How do cooperative stepwise interactions contribute to the speed of protein folding?

How does the time required for random trial and error folding compare to the actual protein folding time?

Design an experiment to test the role of the hydrophobic effect in protein folding.

Propose a mechanism by which cooperative stepwise interactions could be experimentally demonstrated in a laboratory setting.