Synthesize the role of phospholipase C in the phosphoenacitide GPCR signaling pathway and its effect on PIP2.

• A. Phospholipase C binds to calcium ions to activate calmodulin.
• B. Phospholipase C converts PIP2 into ATP.
• C. Phospholipase C hydrolyzes PIP2 to produce IP3 and DAG, which act as secondary messengers in the signaling pathway.
• D. Phospholipase C phosphorylates PIP2 to activate PKC.

Answer: (C)