Question 1

Which of the following best describes an autosomal disorder?

Accepted Answer

A disorder caused by a gene located on a non-sex chromosome.

Question 2

A genetic counselor observes that a certain disorder appears in every generation of a pedigree. What is the most likely mode of inheritance?

Accepted Answer

Autosomal dominant

Question 3

If both parents are heterozygous for an autosomal recessive disorder, what is the probability that their child will be affected?

Accepted Answer

$$\frac{1}{4}$$

Question 4

Which of the following genotypes would result in an individual expressing an autosomal dominant disorder?

Accepted Answer

AA or Aa

Question 5

A pedigree shows two unaffected parents having an affected child. What is the most likely inheritance pattern?

Accepted Answer

Autosomal recessive

Question 6

In the context of autosomal inheritance, what does the genotype 'Aa' represent?

Accepted Answer

A heterozygous individual

Question 7

Which of the following statements about cystic fibrosis is correct?

Accepted Answer

It is an autosomal recessive disorder.

Question 8

A pedigree shows that only individuals with two affected parents are affected by a certain disorder. Which inheritance pattern does this suggest?

Accepted Answer

Autosomal recessive

Question 9

If a child has blood type O, and one parent has blood type AB, what is the possible genotype of the other parent?

Accepted Answer

The other parent must have genotype $$ii ($$blood type O).

Question 10

Which of the following is NOT a characteristic of autosomal dominant inheritance?

Accepted Answer

Affected individuals must have two affected parents.

Question 11

A pedigree shows that a disorder affects both males and females equally and skips generations. What is the most likely explanation?

Accepted Answer

The disorder is autosomal recessive.

Question 12

If an individual with genotype $$Aa ($$for an autosomal dominant disorder) has children with an individual with genotype $$aa$$, what is the probability that their child will be affected?

Accepted Answer

$$\frac{1}{2}$$

Question 13

Which of the following best explains why autosomal recessive disorders can appear in children whose parents do not show the disorder?

Accepted Answer

Both parents are carriers of the recessive allele.

Question 14

A pedigree analysis reveals that all affected individuals have at least one affected parent. What is the most likely mode of inheritance?

Accepted Answer

Autosomal dominant

Question 15

Which of the following genotypes is NOT possible for a person with blood type A?

Accepted Answer

$$IBIB$$

Question 16

If two individuals with genotype $$IAIB ($$blood type AB) have a child, what is the probability that the child will have blood type O?

Accepted Answer

$$0$$

Question 17

Which of the following is a key difference between autosomal dominant and autosomal recessive inheritance patterns?

Accepted Answer

Autosomal dominant disorders appear in every generation, while autosomal recessive disorders can skip generations.

Question 18

A pedigree shows that a disorder is present in both males and females, but only when both parents are carriers. Which inheritance pattern does this suggest?

Accepted Answer

Autosomal recessive

Question 19

Which of the following best describes the genotype of an individual with blood type AB?

Accepted Answer

$$IAIB$$

Question 20

If a pedigree shows that a disorder is inherited equally by males and females and is present in every generation, what is the most likely mode of inheritance?

Accepted Answer

Autosomal dominant

Autosomal Inheritance and Pedigree Analysis

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