Question 1

Which of the following oncogenes is most commonly associated with chronic myelogenous leukemia?

Accepted Answer

ABL

Question 2

A patient is diagnosed with a gastrointestinal stromal tumor syndrome. Which oncogene is most likely mutated in this case?

Accepted Answer

KIT

Question 3

Which of the following best describes the function of the KRAS oncogene?

Accepted Answer

GTPase

Question 4

A mutation in which oncogene is most likely to be found in a patient with hereditary papillary renal carcinoma?

Accepted Answer

MET

Question 5

Which oncogene is associated with both neuroblastoma and breast carcinoma?

Accepted Answer

ERBB2 (HER2/neu)

Question 6

A mutation in which gene is most likely to result in malignant melanoma?

Accepted Answer

BRAF

Question 7

Which of the following oncogenes encodes a protein that interacts with JUN oncogene to regulate transcription?

Accepted Answer

FOS

Question 8

A patient with thyroid carcinoma is found to have a mutation in a receptor tyrosine kinase gene. Which gene is most likely mutated?

Accepted Answer

RET

Question 9

Which oncogene is associated with acute promyelocytic leukemia?

Accepted Answer

ERBA

Question 10

A mutation in which gene is most likely to be found in Kaposi sarcoma?

Accepted Answer

KS3

Question 11

Which of the following best describes the function of the ABL oncogene?

Accepted Answer

Protein kinase

Question 12

A patient with colon cancer is most likely to have a mutation in which of the following oncogenes?

Accepted Answer

KRAS

Question 13

Which oncogene is associated with both lymphoma and leukemia?

Accepted Answer

MYB

Question 14

A mutation in which gene is most likely to be found in osteosarcoma?

Accepted Answer

FOS

Question 15

Which of the following oncogenes is a cyclin-dependent kinase associated with malignant melanoma?

Accepted Answer

CDK4

Question 16

A mutation in which gene is most likely to be found in glioblastoma (brain tumor)?

Accepted Answer

ERBB

Question 17

Which of the following oncogenes is a DNA-binding protein associated with neuroblastoma and lung carcinoma?

Accepted Answer

MYC

Question 18

A mutation in which gene is most likely to be found in acute monocytic leukemia?

Accepted Answer

KRAS

Question 19

Which of the following best describes the function of the SIS oncogene?

Accepted Answer

$$\beta$$ subunit of platelet-derived growth factor

Question 20

A mutation in which gene is most likely to be found in hereditary papillary renal carcinoma?

Accepted Answer

MET

Oncogenes and Their Roles in Cancer

Study Guide - Practice Questions