In the process of glycolysis, fructose is converted to fructose 1-phosphate in the first step. How does this conversion hinder the passive diffusion of fructose out of the cell?

• A. Fructose 1-phosphate is a small, non-polar, and non-charged molecule, making it difficult to pass through the hydrophobic lipid bilayer of the cell membrane.
• B. Fructose 1-phosphate is a large, polar, and charged molecule, making it difficult to pass through the hydrophobic lipid bilayer of the cell membrane.
• C. Fructose 1-phosphate is a hydrophilic, small, and charged molecule that does not readily cross the hydrophobic lipid bilayer of the cell membrane.
• D. Fructose 1-phosphate is a non-charged, hydrophobic molecule that does not readily cross the hydrophobic lipid bilayer of the cell membrane.

Answer: (B)