Question 1

Which of the following statements best describes a primary amine?

Accepted Answer

A nitrogen atom bonded to one alkyl group and two hydrogens.

Question 2

Which property of amines allows them to be more soluble in water than hydrocarbons of similar molecular weight?

Accepted Answer

Their ability to form hydrogen bonds with water.

Question 3

At physiological pH ($pH = 7.4$), which form of methylamine ($pK_a = 10.62$) will predominate in blood?

Accepted Answer

The protonated ammonium ion form ($CH_3NH_3^+$)

Question 4

Which of the following is TRUE about quaternary ammonium salts?

Accepted Answer

They carry a formal $+1$ charge and do not have a $pK_a$.

Question 5

Which neurotransmitter is derived from the amino acid tyrosine and is associated with motor coordination?

Accepted Answer

Dopamine

Question 6

Which of the following best explains why tertiary amines cannot form hydrogen bonds with one another?

Accepted Answer

They do not have any N-H bonds.

Question 7

Which of the following is a cyclic amide known as a lactam?

Accepted Answer

Penicillin

Question 8

Amines react with strong acids to form:

Accepted Answer

Ammonium salts

Question 9

Which of the following is the correct equilibrium expression for the base dissociation of a primary amine ($CH_3NH_2$) in water?

Accepted Answer

$K_b = \frac{[CH_3NH_3^+][OH^-]}{[CH_3NH_2]}$

Question 10

Which of the following statements about amides is CORRECT?

Accepted Answer

Amides are formed by the reaction of an amine with a carboxylic acid, but this reaction is slow at room temperature.

Question 11

Which of the following is a reason why the reaction of an amine with an anhydride is faster than with a carboxylic acid?

Accepted Answer

Anhydrides are more reactive due to better leaving groups.

Question 12

Which of the following is NOT a property of amines?

Accepted Answer

They are always completely insoluble in water.

Question 13

Which of the following best describes the functional group of an amide?

Accepted Answer

A carbonyl group ($C=O$) bonded to a nitrogen atom.

Question 14

Which of the following statements about neurotransmitters is TRUE?

Accepted Answer

Neurotransmitters are released at the synapse and bind to receptors on the target cell.

Question 15

Which of the following is a consequence of decreased dopamine production in the brain?

Accepted Answer

Decreased motor coordination and symptoms of Parkinson's disease.

Question 16

Which of the following is TRUE regarding the solubility of amines in water?

Accepted Answer

Low molecular weight amines are completely soluble in water.

Question 17

Which of the following is a heterocyclic aromatic amine found in DNA?

Accepted Answer

Thymine

Question 18

Which of the following is the correct product when ethylamine reacts with hydrochloric acid?

Accepted Answer

Ethylammonium chloride ($CH_3CH_2NH_3^+Cl^-$)

Question 19

Which of the following is a correct statement about the hydrolysis of amides?

Accepted Answer

Amides can be hydrolyzed by both acids and bases to yield carboxylic acids or their salts.

Amines and Amides: Structure, Properties, and Biological Roles

Study Guide - Practice Questions