How do Pattern Recognition Receptors (PRRs), including Toll-like receptors (TLRs), function in the innate immune system?

• A. They bind to antibodies and facilitate the destruction of pathogens.
• B. They are responsible for the production of cytokines in response to infection.
• C. They directly destroy pathogens by forming pores in their membranes.
• D. They recognize PAMPs on pathogens and initiate an immune response.

Answer: (D)