Domanda del libro di testo
Kornberg showed that nucleotides are added to the 3' end of each growing DNA strand. In what way does an exposed 3'-OH group participate in strand elongation?
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Ch. 10 - DNA Replication
Klug10th EditionEssentials of GeneticsISBN: 9780135588789
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TOC.tableOfContents
- Ch. 1 - Introduction to Genetics16
- Ch. 2 - Mitosis and Meiosis28
- Ch. 3 - Mendelian Genetics37
- Ch. 4 - Modification of Mendelian Ratios53
- Ch. 5 - Sex Determination and Sex Chromosomes32
- Ch. 6 - Chromosome Mutations: Variation in Number and Arrangement37
- Ch. 7 - Linkage and Chromosome Mapping in Eukaryotes36
- Ch. 8 - Genetic Analysis and Mapping in Bacteria and Bacteriophages24
- Ch. 9 - DNA Structure and Analysis38
- Ch. 10 - DNA Replication29
- Ch. 11 - Chromosome Structure and DNA Sequence Organization22
- Ch. 12 - The Genetic Code and Transcription36
- Ch. 13 - Translation and Proteins27
- Ch. 14 - Gene Mutation, DNA Repair, and Transposition34
- Ch. 15 - Regulation of Gene Expression in Bacteria22
- Ch. 16 - Regulation of Gene Expression in Eukaryotes37
- Ch. 17 - Recombinant DNA Technology27
- Ch. 18 - Genomics, Bioinformatics, and Proteomics30
- Ch. 19 - The Genetics of Cancer21
- Ch. 20 - Quantitative Genetics and Multifactorial Traits37
- Ch. 21 - Population and Evolutionary Genetics45
Klug10th EditionEssentials of GeneticsISBN: 9780135588789Non è quello che usi tu?Cambia libro di testo
Capitolo 10, Problema 12
Summarize and compare the properties of DNA polymerase I, II, and III.
Guida verificata passo dopo passo1
Start by identifying the primary function of each DNA polymerase enzyme in prokaryotes, focusing on DNA polymerase I, II, and III.
Describe DNA polymerase I, emphasizing its role in removing RNA primers through its 5' to 3' exonuclease activity and filling in the resulting gaps with DNA.
Explain DNA polymerase II, noting its function mainly in DNA repair and its 3' to 5' exonuclease proofreading activity to maintain DNA fidelity.
Detail DNA polymerase III as the main enzyme responsible for the bulk of DNA synthesis during replication, highlighting its high processivity and 3' to 5' exonuclease proofreading activity.
Compare the enzymes by summarizing their exonuclease activities, roles in replication versus repair, and their relative importance in the DNA replication process.
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DNA Polymerase I
DNA Polymerase I is primarily involved in DNA repair and the removal of RNA primers during replication. It has 5' to 3' polymerase activity, 3' to 5' exonuclease proofreading, and unique 5' to 3' exonuclease activity that removes RNA primers, allowing replacement with DNA.
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Percorso guidato
01:45
DNA Proofreading
DNA Polymerase II
DNA Polymerase II functions mainly in DNA repair and replication restart after damage. It possesses 5' to 3' polymerase and 3' to 5' exonuclease proofreading activities but lacks 5' to 3' exonuclease activity, making it less involved in primer removal.
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Percorso guidato
01:45DNA Proofreading
DNA Polymerase III
DNA Polymerase III is the primary enzyme responsible for bacterial DNA replication. It has high processivity and 5' to 3' polymerase activity, along with 3' to 5' exonuclease proofreading, but lacks 5' to 3' exonuclease activity, so it cannot remove RNA primers.
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Percorso guidato
01:45DNA Proofreading
Pratica correlata
Domanda del libro di testo
List and describe the function of the ten subunits constituting DNA polymerase III. Distinguish between the holoenzyme and the core enzyme.
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Domanda del libro di testo
Which characteristics of DNA polymerase I raised doubts that its in vivo function is the synthesis of DNA leading to complete replication?
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Domanda del libro di testo
List the proteins that unwind DNA during in vivo DNA synthesis. How do they function?
978
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Domanda del libro di testo
What was the significance of the polA1 mutation?
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Domanda del libro di testo
Distinguish between
(a) unidirectional and bidirectional synthesis, and
(b) continuous and discontinuous synthesis of DNA.
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