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Assuming that each nucleotide in an mRNA is 0.34 nm long, how many triplet codes can simultaneously occupy the space in a ribosome that is 20 nm in diameter?
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Ch. 13 - Translation and Proteins
Klug10th EditionEssentials of GeneticsISBN: 9780135588789
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TOC.tableOfContents
- Ch. 1 - Introduction to Genetics16
- Ch. 2 - Mitosis and Meiosis28
- Ch. 3 - Mendelian Genetics37
- Ch. 4 - Modification of Mendelian Ratios53
- Ch. 5 - Sex Determination and Sex Chromosomes32
- Ch. 6 - Chromosome Mutations: Variation in Number and Arrangement37
- Ch. 7 - Linkage and Chromosome Mapping in Eukaryotes36
- Ch. 8 - Genetic Analysis and Mapping in Bacteria and Bacteriophages24
- Ch. 9 - DNA Structure and Analysis38
- Ch. 10 - DNA Replication29
- Ch. 11 - Chromosome Structure and DNA Sequence Organization22
- Ch. 12 - The Genetic Code and Transcription36
- Ch. 13 - Translation and Proteins27
- Ch. 14 - Gene Mutation, DNA Repair, and Transposition34
- Ch. 15 - Regulation of Gene Expression in Bacteria22
- Ch. 16 - Regulation of Gene Expression in Eukaryotes37
- Ch. 17 - Recombinant DNA Technology27
- Ch. 18 - Genomics, Bioinformatics, and Proteomics30
- Ch. 19 - The Genetics of Cancer21
- Ch. 20 - Quantitative Genetics and Multifactorial Traits37
- Ch. 21 - Population and Evolutionary Genetics45
Klug10th EditionEssentials of GeneticsISBN: 9780135588789Non è quello che usi tu?Cambia libro di testo
Capitolo 13, Problema 12
Using sickle-cell anemia as an example, describe what is meant by a molecular or genetic disease. What are the similarities and dissimilarities between this type of a disorder and a disease caused by an invading microorganism?
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Step 1: Define a molecular or genetic disease by explaining that it is caused by mutations or alterations in the DNA sequence of a gene, which leads to abnormal protein function or production. Use sickle-cell anemia as an example, where a single nucleotide mutation in the hemoglobin gene causes the production of abnormal hemoglobin protein.
Step 2: Describe how this mutation affects the structure and function of hemoglobin, leading to the characteristic sickle shape of red blood cells, which impairs their ability to carry oxygen and causes various symptoms of the disease.
Step 3: Explain that diseases caused by invading microorganisms, such as bacteria or viruses, result from external infectious agents entering the body and disrupting normal physiological processes, unlike genetic diseases which originate from internal genetic defects.
Step 4: Compare similarities by noting that both types of diseases can cause significant health problems, may have genetic susceptibility factors, and can trigger immune responses in the body.
Step 5: Highlight dissimilarities by emphasizing that genetic diseases are inherited and present from birth due to DNA mutations, whereas infectious diseases are acquired through exposure to pathogens and are not inherited. Also, treatment approaches differ, with genetic diseases often requiring gene therapy or symptom management, while infectious diseases may be treated with antibiotics or antivirals.
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Molecular or Genetic Disease
A molecular or genetic disease arises from mutations or alterations in an individual's DNA that affect the structure or function of proteins. These diseases are inherited or occur due to spontaneous genetic changes, leading to abnormal cellular processes, as seen in sickle-cell anemia where a mutation in the hemoglobin gene causes defective red blood cells.
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Descriptive Genetics
Sickle-Cell Anemia as a Genetic Disorder
Sickle-cell anemia is caused by a single point mutation in the beta-globin gene, resulting in abnormal hemoglobin (HbS). This causes red blood cells to become rigid and sickle-shaped, impairing oxygen transport and leading to symptoms like pain and anemia. It exemplifies how a single genetic change can have systemic effects.
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Differences and Similarities Between Genetic Diseases and Infectious Diseases
Genetic diseases originate from internal DNA mutations and are inherited or spontaneous, while infectious diseases result from external pathogens like bacteria or viruses invading the body. Both can cause cellular dysfunction and symptoms, but genetic diseases are not contagious, whereas infectious diseases can spread between individuals.
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