Domanda del libro di testo
What evidence did Watson and Crick have at their disposal in 1953? What was their approach in arriving at the structure of DNA?
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Ch. 10 - DNA Structure and Analysis
Klug12th EditionConcepts of GeneticsISBN: 9780135564776
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TOC.tableOfContents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
Klug12th EditionConcepts of GeneticsISBN: 9780135564776Non è quello che usi tu?Cambia libro di testo
Capitolo 10, Problema 13
Draw the chemical structure of a dinucleotide composed of A and G. Opposite this structure, draw the dinucleotide composed of T and C in an antiparallel (or upside-down) fashion. Form the possible hydrogen bonds.
Guida verificata passo dopo passo1
Step 1: Begin by drawing the chemical structure of the first dinucleotide composed of adenine (A) and guanine (G). Each nucleotide consists of three parts: a phosphate group, a deoxyribose sugar, and a nitrogenous base (A or G). Connect the phosphate group of the first nucleotide to the 5' carbon of its sugar, and link the 3' carbon of the sugar to the phosphate group of the next nucleotide, forming a phosphodiester bond between A and G.
Step 2: Next, draw the complementary dinucleotide composed of thymine (T) and cytosine (C) in an antiparallel orientation relative to the first strand. This means the 5' end of the T-C strand aligns opposite the 3' end of the A-G strand, so the sugar-phosphate backbone runs in the opposite direction.
Step 3: Position the nitrogenous bases of the two strands so that adenine (A) pairs opposite thymine (T), and guanine (G) pairs opposite cytosine (C). Remember that A-T pairs form two hydrogen bonds, while G-C pairs form three hydrogen bonds.
Step 4: Illustrate the hydrogen bonds between the complementary bases. For A-T, draw two dashed lines representing the two hydrogen bonds; for G-C, draw three dashed lines representing the three hydrogen bonds. These bonds stabilize the double-stranded structure.
Step 5: Review the entire structure to ensure correct antiparallel orientation, proper phosphodiester linkages, and accurate base pairing with hydrogen bonds. This completes the depiction of the dinucleotide duplex with complementary base pairing.
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Dinucleotide Structure
A dinucleotide consists of two nucleotides linked by a phosphodiester bond between the 3' hydroxyl of one sugar and the 5' phosphate of the next. Each nucleotide includes a sugar (deoxyribose in DNA), a phosphate group, and a nitrogenous base (A, T, G, or C). Understanding this structure is essential to accurately draw the backbone and base components.
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03:49
Ribosome Structure
Antiparallel Orientation of DNA Strands
DNA strands run in opposite directions, with one strand oriented 5' to 3' and the complementary strand 3' to 5'. This antiparallel arrangement is crucial when positioning dinucleotides opposite each other, ensuring proper alignment of bases for hydrogen bonding.
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03:03Double Strand Breaks
Base Pairing and Hydrogen Bonding
In DNA, adenine (A) pairs with thymine (T) via two hydrogen bonds, and guanine (G) pairs with cytosine (C) via three hydrogen bonds. These specific interactions stabilize the double helix and must be shown when drawing complementary dinucleotides in antiparallel orientation.
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03:49Base Distortions
Pratica correlata
Domanda del libro di testo
Adenine may also be named 6-amino purine. How would you name the other four nitrogenous bases, using this alternative system? (O is indicated by 'oxy-,' and CH₃ by 'methyl.')
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Domanda del libro di testo
What might Watson and Crick have concluded had Chargaff's data from a single source indicated the following?
Why would this conclusion be contradictory to Wilkins's and Franklin's data?
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Domanda del libro di testo
How are the carbon and nitrogen atoms of the sugars, purines, and pyrimidines numbered?
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Domanda del libro di testo
Draw the chemical structure of the three components of a nucleotide, and then link the three together. What atoms are removed from the structures when the linkages are formed?
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Domanda del libro di testo
Describe the various characteristics of the Watson–Crick double-helix model for DNA.
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