Skip to main content
Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Non è quello che usi tu?Cambia libro di testo
Tutti i libri di testoSanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblema C.7b
Capitolo 14, Problema C.7b

Why do most cancers require the mutation of multiple genes?

Guida verificata passo dopo passo
1
Understand that cancer is a complex disease characterized by uncontrolled cell growth and division, which results from genetic mutations affecting cellular functions.
Recognize that multiple genes are involved in regulating cell cycle, DNA repair, apoptosis (programmed cell death), and other critical cellular processes that maintain normal cell behavior.
Identify that mutations in a single gene are often insufficient to cause cancer because cells have redundant and overlapping mechanisms to prevent abnormal growth.
Learn that for a cell to become cancerous, mutations typically need to accumulate in several key types of genes, such as oncogenes (which promote cell division when activated) and tumor suppressor genes (which inhibit cell division or promote apoptosis when functioning properly).
Conclude that the requirement for multiple gene mutations arises because cancer development involves overcoming multiple cellular safeguards, and only the combined effect of these mutations leads to the loss of normal growth control.

Risposta video verificata per un problema simile:

Questa soluzione video è stata consigliata dai nostri tutor come utile per risolvere questo problema.
Durata del video:
1m

Concetti chiave

Ecco i concetti essenziali che devi comprendere per rispondere correttamente alla domanda.

Multistep Nature of Cancer Development

Cancer typically arises through a series of genetic changes rather than a single mutation. Multiple mutations accumulate over time, each contributing to the transformation of normal cells into malignant ones by disrupting various cellular processes.
Video consigliato:
Percorso guidato
09:46
Cancer Characteristics

Oncogenes and Tumor Suppressor Genes

Cancer involves mutations in oncogenes, which promote cell growth, and tumor suppressor genes, which inhibit growth or repair DNA. Both types of genes must be altered to override normal cell regulation and allow uncontrolled proliferation.
Video consigliato:
Percorso guidato
09:09
Mapping Genes

Genetic Instability and Mutation Accumulation

Genetic instability in cells increases mutation rates, enabling the accumulation of multiple gene mutations. This instability is crucial for cancer progression, as it allows cells to acquire the diverse mutations needed to evade growth controls and resist cell death.
Video consigliato:
Percorso guidato
04:46
Cancer Mutations
Pratica correlata
Domanda del libro di testo

The inheritance of certain mutations of BRCA1 can make it much more likely that a woman will develop breast or ovarian cancer in her lifetime. Can you say with certainty that a woman inheriting a mutation of BRCA1 will definitely develop breast or ovarian cancer in her lifetime? Why or why not?

452
views
Domanda del libro di testo

Based on what you read in this chapter, Can a tumor arise from a single mutated cell? Are all the cells in a tumor identical?

493
views
Domanda del libro di testo

Do you think it is important that participation in community-based genetic screening be entirely voluntary? Why or why not?

481
views
Domanda del libro di testo

Diagram the mechanism by which CRISPR–Cas functions in the immune system of bacteria and archaea.

668
views
Domanda del libro di testo

Describe how CRISPR–Cas has been modified to create a genome-editing tool.

724
views
Domanda del libro di testo

Radiation is frequently used as part of the treatment of cancer. The radiation works by damaging DNA and components of the cell. How can radiation treatment control or cure cancer?

597
views