Domanda del libro di testo
The meat tenderizer used in cooking is primarily papain, a protease enzyme isolated from the fruit of the papaya tree. Why do you suppose papain is so effective at tenderizing meat?
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Ch.19 Enzymes and Vitamins
McMurry8th EditionFundamentals of General, Organic, and Biological ChemistryISBN: 9780134015187
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TOC.tableOfContents
- Ch.1 Matter and Measurements27
- Ch.2 Atoms and the Periodic Table20
- Ch.3 Ionic Compounds8
- Ch.4 Molecular Compounds23
- Ch.5 Classification & Balancing of Chemical Reactions12
- Ch.6 Chemical Reactions: Mole and Mass Relationships28
- Ch.7 Chemical Reactions: Energy, Rate and Equilibrium64
- Ch.8 Gases, Liquids and Solids24
- Ch.9 Solutions52
- Ch.10 Acids and Bases25
- Ch.11 Nuclear Chemistry22
- Ch.12 Introduction to Organic Chemistry: Alkanes57
- Ch.13 Alkenes, Alkynes, and Aromatic Compounds47
- Ch.14 Some Compounds with Oxygen, Sulfur, or a Halogen50
- Ch.15 Aldehydes and Ketones45
- Ch.16 Amines42
- Ch.17 Carboxylic Acids and Their Derivatives57
- Ch.18 Amino Acids and Proteins82
- Ch.19 Enzymes and Vitamins63
- Ch.20 Carbohydrates44
- Ch.21 The Generation of Biochemical Energy65
- Ch.22 Carbohydrate Metabolism45
- Ch.23 Lipids42
- Ch.24 Lipid Metabolism33
- Ch.25 Protein and Amino Acid Metabolism24
- Ch.26 Nucleic Acids and Protein Synthesis45
McMurry8th EditionFundamentals of General, Organic, and Biological ChemistryISBN: 9780134015187Non è quello che usi tu?Cambia libro di testo
Capitolo 19, Problema 59c
What kind of inhibition (uncompetitive, competitive, or irreversible) is present in each of the following:
c. The antibiotic deoxycycline inhibits the bacterial enzyme collagenase, slowing bacterial growth. Deoxycycline does not fit into the active site of collagenase and binds elsewhere on the enzyme.
Guida verificata passo dopo passo1
Understand the types of enzyme inhibition: Competitive inhibition occurs when an inhibitor competes with the substrate for the active site. Uncompetitive inhibition occurs when the inhibitor binds only to the enzyme-substrate complex. Irreversible inhibition involves a permanent binding of the inhibitor to the enzyme, rendering it inactive.
Analyze the information provided: The problem states that deoxycycline does not fit into the active site of collagenase and binds elsewhere on the enzyme. This rules out competitive inhibition, as competitive inhibitors bind to the active site.
Consider the mechanism of action: Since deoxycycline binds to a site other than the active site, it is likely altering the enzyme's structure or function indirectly. This is characteristic of non-competitive inhibition, which is a subtype of reversible inhibition.
Evaluate whether the inhibition is reversible or irreversible: The problem does not mention that deoxycycline permanently inactivates collagenase, so it is unlikely to be irreversible inhibition.
Conclude the type of inhibition: Based on the information, the inhibition described is most consistent with non-competitive inhibition, as the inhibitor binds to a different site on the enzyme and does not compete with the substrate for the active site.
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Enzyme Inhibition
Enzyme inhibition refers to the process by which a molecule (inhibitor) decreases the activity of an enzyme. This can occur through various mechanisms, including competitive, uncompetitive, and irreversible inhibition, each affecting the enzyme's function in different ways. Understanding these mechanisms is crucial for analyzing how drugs, like antibiotics, interact with bacterial enzymes.
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1:19
Enzyme Inhibition Concept 1
Competitive Inhibition
Competitive inhibition occurs when an inhibitor competes with the substrate for binding to the active site of an enzyme. This type of inhibition can be overcome by increasing the concentration of the substrate. In the context of the question, competitive inhibitors directly block the active site, which is not the case for deoxycycline.
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1:19Enzyme Inhibition Concept 1
Allosteric Inhibition
Allosteric inhibition occurs when an inhibitor binds to a site other than the active site, causing a conformational change in the enzyme that reduces its activity. This is relevant to the question, as deoxycycline binds elsewhere on collagenase, indicating that it functions as an allosteric inhibitor rather than a competitive one.
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1:19Enzyme Inhibition Concept 1
Pratica correlata
Domanda del libro di testo
The text discusses three forms of enzyme inhibition: uncompetitive inhibition, competitive inhibition, and irreversible inhibition.
b. What kinds of bonds are formed between an enzyme and each of these three kinds of inhibitors?
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Domanda del libro di testo
One mechanism by which lead exerts its poisonous effect on enzymes can be stopped by chelation therapy with EDTA. Describe this type of lead poisoning and explain why it is reversible.
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Domanda del libro di testo
What kind of inhibition (uncompetitive, competitive, or irreversible) is present in each of the following:
a. Penicillin is used to treat certain bacterial infections. Penicillin is effective because it binds to the enzyme glycopeptide transpeptidase and does not dissociate.
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Domanda del libro di testo
Why do allosteric enzymes have two types of binding sites?
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Domanda del libro di testo
What general effects would you expect the following changes to have on the rate of an enzyme-catalyzed reaction for an enzyme that has its maximum activity at body temperature (about 37°C)?
c. Adding an oxidizing agent, such as hydrogen peroxide
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