Which of the following would be the first step in the biosynthesis of a virus with reverse transcriptase?
a. A complementary strand of RNA must be synthesized.
b. Double-stranded RNA must be synthesized.
c. A complementary strand of DNA must be synthesized from an RNA template.
d. A complementary strand of DNA must be synthesized from a DNA template.
e. None of the above

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Understand that viruses with reverse transcriptase, such as retroviruses, have an RNA genome that needs to be converted into DNA inside the host cell.

Recall that reverse transcriptase is an enzyme that synthesizes DNA from an RNA template, which is the reverse of the usual transcription process.

Identify that the first step in the biosynthesis of such a virus involves creating a complementary DNA strand from the viral RNA genome.

Recognize that this step is crucial because the newly synthesized DNA can then integrate into the host genome for further replication and transcription.

Conclude that the correct first step is the synthesis of a complementary DNA strand from an RNA template, corresponding to option c.

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