Domanda del libro di testo
Using IUPAC rules, name the following molecules.
(b)
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Ch. 13 - Alcohols, Ethers and Related Compounds: Substitution and Elimination
Mullins1st EditionOrganic Chemistry: A Learner Centered ApproachISBN: 9780137566471
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TOC.tableOfContents
- Ch. 2 - General Chemistry Translated: Finding the Electrons114
- Ch. 3 - Alkanes and Cycloalkanes: Properties and Conformational Analysis109
- Ch. 4 - Acids and Bases/Electron Flow144
- Ch. 5 - Chemical Reaction Analysis: Thermodynamics and Kinetics118
- Ch. 6 - Stereoisomerism: Arrangement of Atoms in Space112
- Ch. 7 - Principles of Green (Organic) Chemistry3
- Ch. 8 - Alkenes 1: Properties and Electrophilic Additions158
- Ch. 9 - Alkenes 2: Oxidation and Reduction150
- Ch. 10 - Alkynes: Electrophilic Addition and Redox Reactions101
- Ch. 11 - Properties and Synthesis of Alkyl Halides: Radical Reactions108
- Ch. 12 - Substitution and Elimination: Reactions of Haloalkanes172
- Ch. 13 - Alcohols, Ethers and Related Compounds: Substitution and Elimination239
- Ch. 14 - Structural Identification 1: Infrared Spectroscopy and Mass Spectrometry54
- Ch. 15 - Structural Identification 2: Nuclear Magnetic Resonance Spectroscopy93
- Ch. 16 - Metals in Organic Chemistry48
- Ch. 17 - Carbonyl Addition Reactions: Aldehydes and Ketones45
- Ch. 18 - Nucleophilic Acyl Substitution 1: Carboxylic Acids18
- Ch. 19 - Nucleophilic Acyl Substitution 2: Carboxylic Acid Derivatives39
- Ch. 20 - Enolates: Carbonyl Addition and Substitution13
- Ch. 21 - Conjugated Systems 1: Stability and Addition Reactions56
- Ch. 22 - Conjugated Systems 2: Pericyclic Reactions54
- Ch. 23 - Benzene 1: Aromatic Stability and Substitution Reactions64
- Ch. 24 - Benzene 2: Reactions Influenced by the Aromatic Ring62
- Ch. 25 - Amines: Structure, Reactions, and Synthesis27
- Ch. 26 - Amino Acids, Proteins, and Peptide Synthesis9
- Ch. 27 - Carbohydrates, Nucleic Acids, and Lipids54
Mullins1st EditionOrganic Chemistry: A Learner Centered ApproachISBN: 9780137566471Non è quello che usi tu?Cambia libro di testo
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Mullins 1st EditionCh. 13 - Alcohols, Ethers and Related Compounds: Substitution and EliminationProblema 84a
Mullins 1st EditionCh. 13 - Alcohols, Ethers and Related Compounds: Substitution and EliminationProblema 84aCapitolo 12, Problema 84a
Show how a protecting group might be used to make these reactions successful.
(a) 
Guida verificata passo dopo passo1
Identify the functional groups in the starting material: The molecule contains a hydroxyl group (OH) and a chloro group (Cl) attached to a benzene ring. The target molecule has an alkyne group instead of the chloro group.
Recognize the need for a protecting group: The hydroxyl group is susceptible to reactions that might interfere with the transformation of the chloro group to an alkyne. Protecting the hydroxyl group will prevent unwanted side reactions.
Select an appropriate protecting group: A common protecting group for alcohols is the silyl ether, such as tert-butyldimethylsilyl (TBS) ether. This group can be introduced using a silyl chloride reagent in the presence of a base.
Perform the protection step: React the starting material with TBS-Cl and a base like imidazole to convert the hydroxyl group into a TBS ether, thus protecting it from further reactions.
Carry out the desired transformation: With the hydroxyl group protected, proceed with the conversion of the chloro group to an alkyne. This can be achieved through a series of reactions, such as elimination to form an alkene followed by a Sonogashira coupling to introduce the alkyne group.
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Protecting Groups
Protecting groups are chemical moieties that temporarily mask reactive functional groups in a molecule, allowing for selective reactions to occur without interference. They are crucial in multi-step organic synthesis, as they enable chemists to control the reactivity of specific sites, ensuring that desired transformations can be achieved without unwanted side reactions.
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02:44
Protecting Groups
Functional Group Reactivity
Different functional groups exhibit varying reactivities under specific conditions. Understanding the reactivity of functional groups is essential for designing synthetic pathways, as it helps predict how a molecule will behave in a reaction. By using protecting groups, chemists can manipulate these reactivities to achieve desired outcomes in complex organic transformations.
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02:36Identifying Functional Groups
Deprotection
Deprotection is the process of removing a protecting group after the desired reaction has taken place. This step is critical in restoring the original functional group for further reactions or for the final product. The choice of protecting group often depends on the conditions required for deprotection, which must be compatible with the other functional groups present in the molecule.
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05:49Mechanism of t-Butyl Ether Protecting Groups.
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A variety of organometallics, which as strong nucleophiles can react with epoxides, are introduced in Chapter 16. Predict the product of these reactions. [Hint: Assume the carbon–metal bond in each is ionic, with the carbon possessing the negative charge.]
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A variety of organometallics, which as strong nucleophiles can react with epoxides, are introduced in Chapter 16. Predict the product of these reactions. [Hint: Assume the carbon–metal bond in each is ionic, with the carbon possessing the negative charge.]
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Show how a protecting group might be used to make these reactions successful.
(b)
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Using IUPAC rules, name the following molecules.
(d)
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