why-is-the-gdp-to-gtp-exchange-in-heterotrimeric-g-proteins-crucial-for-adenylat

Question

Why is the GDP to GTP exchange in heterotrimeric G proteins crucial for adenylate cyclase activation?

Accepted Answer

It allows the alpha subunit to dissociate and activate adenylate cyclase.

Answer

It inhibits the binding of epinephrine to GPCR.

Answer

It directly converts ATP into cAMP.

Answer

It prevents the activation of protein kinase A.