Analyze the interaction between PIP3 and PKB/PDK1 in insulin signaling.

PIP3 directly phosphorylates PKB and PDK1, activating them.

PIP3 binds to PKB and PDK1, leading to their activation and subsequent signaling.

PIP3 is converted back to PIP2, which then activates PKB and PDK1.

PIP3 inhibits PKB and PDK1, preventing their activation.