what-is-the-role-of-grb2-in-insulin-signaling-and-how-does-it-interact-with-irs-

Question

What is the role of GRB2 in insulin signaling, and how does it interact with IRS 1?

Accepted Answer

GRB2 binds to phosphorylated IRS 1 via its SH2 domain, linking it to downstream signaling molecules.

Answer

GRB2 inhibits IRS 1 by binding to it, preventing further signaling.

Answer

GRB2 dephosphorylates IRS 1, terminating the signal.

Answer

GRB2 phosphorylates IRS 1, enhancing its signaling capacity.