in-a-scenario-where-the-oxyanion-hole-is-mutated-what-would-be-the-likely-effect

Question

In a scenario where the oxyanion hole is mutated, what would be the likely effect on chymotrypsin's catalytic efficiency?

Accepted Answer

Decreased efficiency due to instability of the tetrahedral intermediate

Answer

Decreased efficiency due to impaired nucleophilic attack

Answer

No effect on efficiency

Answer

Increased efficiency due to enhanced substrate binding